(±)-2-Hydroxyglutaric acid

Modify Date: 2024-01-04 21:26:53

(±)-2-Hydroxyglutaric acid structure	Common Name	(±)-2-Hydroxyglutaric acid
	CAS Number	40951-21-1	Molecular Weight	148.114
	Density	1.5±0.1 g/cm3	Boiling Point	394.2±27.0 °C at 760 mmHg
	Molecular Formula	C₅H₈O₅	Melting Point	>290ºC (dec.)
	MSDS	N/A	Flash Point	206.4±20.2 °C

Use of (±)-2-Hydroxyglutaric acid

α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

Name	2-Hydroxyglutaric Acid Disodium Salt
Synonym	More Synonyms

Description	α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	Microbial Metabolite Human Endogenous Metabolite
In Vitro	Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium, respectively[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of TET 5-methylcytosine hydroxylases[1]. Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) disodium increases HIF-1α and decreases endostatin[1].
References	[1]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

Density	1.5±0.1 g/cm3
Boiling Point	394.2±27.0 °C at 760 mmHg
Melting Point	>290ºC (dec.)
Molecular Formula	C₅H₈O₅
Molecular Weight	148.114
Flash Point	206.4±20.2 °C
Exact Mass	148.037170
PSA	94.83000
LogP	-1.45
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.520

(±)-2-Hydroxyglutaric acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA3751000

CHEMICAL NAME :: Glutaric acid, 2-hydroxy-, disodium salt, L-alpha-

CAS REGISTRY NUMBER :: 40951-21-1

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H6-O5.Na2

MOLECULAR WEIGHT :: 192.09

WISWESSER LINE NOTATION :: OVYQ2VO &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 36,61,1973

L-glutamic acid

CAS#:56-86-0

~63%

(±)-2-Hydroxygl...

CAS#:40951-21-1

Literature: Heizmann, Gerhard; Pfleiderer, Wolfgang Helvetica Chimica Acta, 2007 , vol. 90, # 10 p. 1856 - 1873

Precursor 1
CAS#:56-86-0 L-glutamic acid
DownStream 0

hydroxyglutaric acid

Pentanedioic acid, 2-hydroxy-

2-Hydroxypentanedioic acid

2-hydroxyglutaric acid

DL-2-Hydroxyglutaric

(RS)-2-Hydroxypentanedioic acid disodium salt Disodium 2-hydroxyglutarate

2-Hydroxy-pentanedioic acid

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (±)-2-Hydroxyglutaric acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

(±)-2-Hydroxyglutaric acid suppliers

(±)-2-Hydroxyglutaric acid price

(±)-2-Hydroxyglutaric acid

Use of (±)-2-Hydroxyglutaric acid

Names