4'-demethylpodophyllotoxin

Modify Date: 2024-01-02 00:18:43

4'-demethylpodophyllotoxin Structure
4'-demethylpodophyllotoxin structure
 Common Name 4'-demethylpodophyllotoxin
CAS Number 40505-27-9 Molecular Weight 400.37900
Density 1.446 g/cm3 Boiling Point 626.5ºC at 760 mmHg
Molecular Formula C21H20O8 Melting Point N/A
MSDS N/A Flash Point 224.4ºC

 Use of 4'-demethylpodophyllotoxin


4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].

 Names

Name 4'-demethylpodophyllotoxin
Synonym More Synonyms

 4'-demethylpodophyllotoxin Biological Activity

Description 4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].
Related Catalog
References

[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23(5): 1147-1152.

[2]. Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.

 Chemical & Physical Properties

Density 1.446 g/cm3
Boiling Point 626.5ºC at 760 mmHg
Molecular Formula C21H20O8
Molecular Weight 400.37900
Flash Point 224.4ºC
Exact Mass 400.11600
PSA 103.68000
LogP 2.10620
Index of Refraction 1.637
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV2476100
CAS REGISTRY NUMBER :
40505-27-9
BEILSTEIN REFERENCE NO. :
0099005
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H20-O8
MOLECULAR WEIGHT :
400.41
WISWESSER LINE NOTATION :
T E5 C665 FVO NO PO OHTT&&J DR DQ CO1 EO1& JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
40 umol/L
REFERENCE :
BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 15,5443,1976

 Synonyms

4-demethylepipodophyllotoxin
4'-O-demethylpodophyllotoxin
4'-Demethylpodophyllotoxin
(5R,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
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