<Suppliers Price>

4'-demethylpodophyllotoxin

Names

[ CAS No. ]:
40505-27-9

[ Name ]:
4'-demethylpodophyllotoxin

[Synonym ]:
4-demethylepipodophyllotoxin
4'-O-demethylpodophyllotoxin
4'-Demethylpodophyllotoxin
(5R,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

Biological Activity

[Description]:

4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23(5): 1147-1152.

[2]. Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.

Chemical & Physical Properties

[ Density]:
1.446 g/cm3

[ Boiling Point ]:
626.5ºC at 760 mmHg

[ Molecular Formula ]:
C21H20O8

[ Molecular Weight ]:
400.37900

[ Flash Point ]:
224.4ºC

[ Exact Mass ]:
400.11600

[ PSA ]:
103.68000

[ LogP ]:
2.10620

[ Index of Refraction ]:
1.637

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV2476100
CAS REGISTRY NUMBER :
40505-27-9
BEILSTEIN REFERENCE NO. :
0099005
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H20-O8
MOLECULAR WEIGHT :
400.41
WISWESSER LINE NOTATION :
T E5 C665 FVO NO PO OHTT&&J DR DQ CO1 EO1& JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
40 umol/L
REFERENCE :
BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 15,5443,1976

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.