M77976
Modify Date: 2025-09-20 17:08:29
M77976 structure
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Common Name | M77976 | ||
|---|---|---|---|---|
| CAS Number | 394237-61-7 | Molecular Weight | 296.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H16N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of M77976M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1]. |
| Name | M77976 |
|---|
| Description | M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1]. |
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| Related Catalog | |
| Target |
IC50: 648 μM (PDK4)[1] |
| In Vitro | M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid[1]. M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4[1]. |
| References |
| Molecular Formula | C17H16N2O3 |
|---|---|
| Molecular Weight | 296.32 |
| InChIKey | GSBFARPNIZUMHA-UHFFFAOYSA-N |
| SMILES | COc1ccc(-c2c(-c3ccc(O)cc3O)n[nH]c2C)cc1 |