Specnuezhenide

Modify Date: 2025-08-25 19:52:23

Specnuezhenide structure	Common Name	Specnuezhenide
	CAS Number	39011-92-2	Molecular Weight	686.655
	Density	1.5±0.1 g/cm3	Boiling Point	893.8±65.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₄₂O₁₇	Melting Point	N/A
	MSDS	N/A	Flash Point	282.0±27.8 °C

Use of Specnuezhenide

Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].

Name	Nuezhenide
Synonym	More Synonyms

Description	Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Inflammation/Immunology
In Vitro	Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells[2].
References	[1]. Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700. [2]. Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21(12). pii: E1756.

Density	1.5±0.1 g/cm3
Boiling Point	893.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₄₂O₁₇
Molecular Weight	686.655
Flash Point	282.0±27.8 °C
Exact Mass	686.242188
PSA	260.59000
LogP	-0.31
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.636
InChIKey	STKUCSFEBXPTAY-RDXZJVGFSA-N
SMILES	CC=C1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CC(=O)OCC1OC(OCCc2ccc(O)cc2)C(O)C(O)C1O

Safety Phrases	24/25
HS Code	29389090

Specnuezhenide

2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside

β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate]

β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate]

2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside

Specneuzhenide