RMI 10874

Modify Date: 2025-08-25 18:07:13

RMI 10874 structure	Common Name	RMI 10874
	CAS Number	38020-45-0	Molecular Weight	370.44200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₆N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RMI 10874

RMI 10874 is a tilorone analogue. Tilorone is a small-molecule, orally bioavailable antiviral agent. RMI 10874 completely abolishes lung colonization of an H-2 negative (GR9.B9) MCA-induced fibrosarcoma clone.

Name	3,6-bis-(2-dimethylaminoethoxy)-xanthen-9-one
Synonym	More Synonyms

Description	RMI 10874 is a tilorone analogue. Tilorone is a small-molecule, orally bioavailable antiviral agent. RMI 10874 completely abolishes lung colonization of an H-2 negative (GR9.B9) MCA-induced fibrosarcoma clone.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Infection
In Vivo	The effect of RMI 10874 (RMI 10,874DA) in the abrogation of the metastatic spread of tumor cells is studied. Pre-treatment of BALB/c mice with the RMI 10,874DA completely eliminates lung colonization of an H-2-negative (GR9.B9) MCA-induced fibrosarcoma clone in an experimental metastasis assay[1]. The effect of a tilorone analogue (RMI 10,874DA) and anti-asialo GM1 serum is studied on the survival of BALB/c and C57B1/6 mice after i.v. injections of different syngeneic murine tumor cells. Natural killer (NK) cell activation in vivo by RMI 10874 prolongs survival and inhibits metastasis formation in mice, even when pretreatment consists of a single dose of the analogue[2]. Tilorone is a small-molecule, orally bioavailable drug that is used clinically as an antiviral[3].
References	[1]. Algarra I, et al. Generation and control of metastasis in experimental tumor systems; inhibition of experimental metastases by a tilorone analogue. Int J Cancer. 1993 May 28;54(3):518-23. [2]. Algarra I, et al. Effect of in vivo activation of natural killer (NK) cells by a tilorone analogue on the survival of mice injected intravenously with different experimental murine tumours. Clin Exp Immunol. 1996 Mar;103(3):499-505. [3]. Ekins S, et al. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection. Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01711-17.

Molecular Formula	C₂₁H₂₆N₂O₄
Molecular Weight	370.44200
Exact Mass	370.18900
PSA	55.15000
LogP	2.82700
InChIKey	ZPLWAZDWGJOBJA-UHFFFAOYSA-N
SMILES	CN(C)CCOc1ccc2c(=O)c3ccc(OCCN(C)C)cc3oc2c1

3,6-bis(2-dimethylaminoethoxy)xanthen-9-one

3,6-Bis-(2-dimethylamino-ethoxy)-xanthen-9-one

RMI 10874

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RMI 10874

Use of RMI 10874

Names

RMI 10874 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.