Sontuzumab structure
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Common Name | Sontuzumab | ||
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CAS Number | 372075-37-1 | Molecular Weight | N/A | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | N/A | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of SontuzumabSontuzumab (AS1402) is a humanised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer[1]. |
Name | Sontuzumab |
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Description | Sontuzumab (AS1402) is a humanised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer[1]. |
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Related Catalog | |
Target |
Kd: ~1 nM (MUC1)[1] |
In Vitro | Sontuzumab (huHMFG-1; 0-25 μg/mL) 对以下细胞诱导抗体依赖性细胞毒性 (ADCC): 乳腺癌细胞 ZR-75-1、乳腺癌患者的三种骨髓源性肿瘤细胞系 (KM22、1590、HG15) 和转染人 MUC1 基因的中国仓鼠卵巢 (CHO) 细胞。在 Sontuzumab 存在时,不表达人类 MUC1 的细胞系对 ADCC 不敏感[1][2]。 |
References |
No Any Chemical & Physical Properties |