372075-37-1
372075-37-1 structure
- Name: Sontuzumab
- Chemical Name: Sontuzumab
- CAS Number: 372075-37-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2019-01-13 19:00:18
- Modify Date: 2024-01-21 10:13:19
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Sontuzumab (AS1402) is a humanised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer[1].
| Name | Sontuzumab |
|---|
| Description | Sontuzumab (AS1402) is a humanised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer[1]. |
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| Related Catalog | |
| Target |
Kd: ~1 nM (MUC1)[1] |
| In Vitro | Sontuzumab (huHMFG-1; 0-25 μg/mL) 对以下细胞诱导抗体依赖性细胞毒性 (ADCC): 乳腺癌细胞 ZR-75-1、乳腺癌患者的三种骨髓源性肿瘤细胞系 (KM22、1590、HG15) 和转染人 MUC1 基因的中国仓鼠卵巢 (CHO) 细胞。在 Sontuzumab 存在时，不表达人类 MUC1 的细胞系对 ADCC 不敏感[1][2]。 |
| References |
| No Any Chemical & Physical Properties |