2-(4-Methyl-1H-imidazol-5-yl)ethanamine

Modify Date: 2024-01-10 00:18:27

2-(4-Methyl-1H-imidazol-5-yl)ethanamine structure	Common Name	2-(4-Methyl-1H-imidazol-5-yl)ethanamine
	CAS Number	36507-31-0	Molecular Weight	125.17
	Density	1.1g/cm3	Boiling Point	345ºC at 760mmHg
	Molecular Formula	C₆H₁₁N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	189.3ºC

Use of 2-(4-Methyl-1H-imidazol-5-yl)ethanamine

4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1][2].

Name	4-methylhistamine
Synonym	More Synonyms

Description	4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349. [2]. Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17.

Description

4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

References

[1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

[2]. Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17.

Density	1.1g/cm3
Boiling Point	345ºC at 760mmHg
Molecular Formula	C₆H₁₁N₃
Molecular Weight	125.17
Flash Point	189.3ºC
Exact Mass	125.09500
PSA	54.70000
LogP	0.91960
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3505600

CHEMICAL NAME :: Imidazole, 4-(2-aminoethyl)-5-methyl-

CAS REGISTRY NUMBER :: 36507-31-0

LAST UPDATED :: 198708

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H11-N3

MOLECULAR WEIGHT :: 125.20

WISWESSER LINE NOTATION :: T5M CNJ D2Z E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 100 umol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

Hazard Codes	Xi
HS Code	2933290090

4-(2-chloroethy...

CAS#:69435-38-7

~79%

2-(4-Methyl-1H-...

CAS#:36507-31-0

Literature: Pfister, Juerg R.; Kurz, Walter; Harrison, Ian T. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 831 - 832

5-Chloro-2-pentanone

CAS#:5891-21-4

2-(4-Methyl-1H-...

CAS#:36507-31-0

Literature: Elz, Sigurd; Schunack, Walter Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242

1- Phthalimido-...

CAS#:3197-25-9

2-(4-Methyl-1H-...

CAS#:36507-31-0

Literature: Elz, Sigurd; Schunack, Walter Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242

N/A

CAS#:126434-97-7

2-(4-Methyl-1H-...

CAS#:36507-31-0

Literature: Elz, Sigurd; Schunack, Walter Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242

3-bromo-5-phtal...

CAS#:112357-34-3

2-(4-Methyl-1H-...

CAS#:36507-31-0

Literature: Elz, Sigurd; Schunack, Walter Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242

Precursor 4
CAS#:69435-38-7 4-(2-chloroethy... CAS#:5891-21-4 5-Chloro-2-pentanone CAS#:3197-25-9 1- Phthalimido-... CAS#:112357-34-3 3-bromo-5-phtal...
DownStream 0

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-Methylhistamine

4-(2-aminoethyl)-5-methyl-1H-imidazole

2-(5-methyl-1(3)H-imidazol-4-yl)-ethylamine

2-(5-methyl-1H-imidazol-4-yl)ethanamine

5-Methylhistamine

2-(5-methyl-1H-imidazol-4-yl)-ethylamine

5(4)-Methylhistamine

1H-Imidazo-4-ethanamine,5-methyl

2-(5-methyl-4-imidazolyl)ethylamine

IMIDAZOLE,4-(2-AMINOETHYL)-5-METHYL

1H-Imidazole-4-ethanamine,5-methyl

2-(5-Methyl-1(3)H-imidazol-4-yl)-aethylamin

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-methylhistamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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2-(4-Methyl-1H-imidazol-5-yl)ethanamine

Use of 2-(4-Methyl-1H-imidazol-5-yl)ethanamine

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