Acetaminophen-13C2,15N

Modify Date: 2024-01-19 18:25:04

Acetaminophen-13C2,15N structure	Common Name	Acetaminophen-13C2,15N
	CAS Number	360769-21-7	Molecular Weight	154.14
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₁₃C₂H₉₁₅NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Acetaminophen-13C2,15N

Acetaminophen-13C2,15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].

Name	Acetaminophen-13C2,15N

Description	Acetaminophen-13C2,15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90. [3]. Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 68:594. [4]. Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 20172017:1796209. [5]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec8(6):553-9.

Molecular Formula	C₆₁₃C₂H₉₁₅NO₂
Molecular Weight	154.14

Acetaminophen-13C2,15N

Use of Acetaminophen-13C2,15N

Names

Acetaminophen-13C2,15N Biological Activity

Chemical & Physical Properties