FR054

Modify Date: 2025-08-25 13:43:53

Use of FR054

FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1].

Name	[(3aR,5R,6S,7R,7aR)-6,7-diacetyloxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazol-5-yl]methyl acetate
Synonym	More Synonyms

Description	FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects[1]. FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells[1]. FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death[1]. Cell Viability Assay[1] Cell Line: MDA-MB-231 cells. Concentration: 0.5-1 mM. Incubation Time: 48 h. Result: Reduced viability and a significant increase of the apoptosis as compared to the control clone.
In Vivo	FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice[1]. Animal Model: Mice were subcutaneously injected with MDA-MB-231 cells[1]. Dosage: 1000 mg/kg. Administration: IP, single or fractionated dose (twice a day 500 mg/kg/dose). Result: Appears to have an in vivo antitumor efficacy that is higher when administered twice a day compared to single administration.
References	[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

Hazard Codes	Xn

wzfqzrlqmxzmja-kstchigdsa

Get all suppliers and price by the below link:

Price: ￥500/5 mg

Reference only. check more FR054 price