Carmoisine

Modify Date: 2024-01-03 00:17:27

Carmoisine Structure
Carmoisine structure
 Common Name Carmoisine
CAS Number 3567-69-9 Molecular Weight 502.428
Density N/A Boiling Point N/A
Molecular Formula C20H12N2Na2O7S2 Melting Point >300ºC
MSDS Chinese USA Flash Point >225℃
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Carmoisine


Carmoisine (Azorubine) is an azo dye that can be used as a food additive[1][2].

 Names

Name Acidic Red B
Synonym More Synonyms

 Carmoisine Biological Activity

Description Carmoisine (Azorubine) is an azo dye that can be used as a food additive[1][2].
Related Catalog
In Vitro Carmoisine augments the in vitro synthesis of leukotriene B4 (LTB4) and F2-isoprostanes from blood neutrophils. Carmoisine increases the formation of F2-isoprostanes from blood neutrophils at all tested concentrations[2].
In Vivo Carmoisine (49.3-493 mg/kg; oral administration; for 42 days; male Wistar rats) treatment increases MAPK8 expression at remarkably low and high concentrations, the expression of NFκB and GADD45α does not change[1]. Animal Model: Male Wistar rats (120-300 g)[1] Dosage: 49.3 mg/kg, 493 mg/kg Administration: Oral administration; for 42 days Result: Resulted in apoptosis according to MAPK8 expression.
References

[1]. B Raposa, et al. Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFκB, GADD45α, and MAPK8 genes. Physiol Int. 2016 Sep;103(3):334-343.

[2]. Latasha Leo, et al. Occurrence of azo food dyes and their effects on cellular inflammatory responses. Nutrition. 2018 Feb;46:36-40.

 Chemical & Physical Properties

Melting Point >300ºC
Molecular Formula C20H12N2Na2O7S2
Molecular Weight 502.428
Flash Point >225℃
Exact Mass 501.988129
PSA 176.11000
LogP 6.08380

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QK1925000
CHEMICAL NAME :
1-Naphthalenesulfonic acid, 4-hydroxy-3,4'-azodi-, disodium salt
CAS REGISTRY NUMBER :
3567-69-9
LAST UPDATED :
199703
DATA ITEMS CITED :
21
MOLECULAR FORMULA :
C20-H12-N2-O7-S2.2Na
MOLECULAR WEIGHT :
502.44
WISWESSER LINE NOTATION :
L66J BSWQ ENUN- CL66J BQ ESWQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
74 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
300 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,83,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,83,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1431 No. of Facilities: 92 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 1771 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1431 No. of Facilities: 2819 (estimated) No. of Industries: 39 No. of Occupations: 49 No. of Employees: 38995 (estimated) No. of Female Employees: 8194 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS QK1925000

 Synthetic Route

1-Naphthol-4-sulfonic acid structure

1-Naphthol-4-su...

CAS#:84-87-7

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Carmoisine Structure

Carmoisine

CAS#:3567-69-9

Literature: DE26012 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 391 Die Anilinfarben und ihre Fabrikation, 4.Tl.,S.787 DE66838 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 791

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles26

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Toxic effects of some synthetic food colorants and/or flavor additives on male rats.

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The objective of the present work was to evaluate the broadest toxic effect of some synthetic additives of colorants and/or flavors on different body organs and metabolic aspects in rats. A number of ...

Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers.

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A double-blind randomized intervention study has previously shown that a significant relationship exists between the consumption of various mixes of seven target additives by children and the onset of...

 Synonyms

Disodium 4-hydroxy-3-((4-sulphonatonaphthyl)azo)naphthalenesulphonate
Carmoisine B
Disodium 4-hydroxy-3-[(E)-(4-sulfonato-1-naphthyl)diazenyl]-1-naphthalenesulfonate
Disodium 4-hydroxy-3-[(E)-(4-sulfonato-1-naphthyl)diazenyl]naphthalene-1-sulfonate
1-Naphthalenesulfonic acid, 4-hydroxy-3-[(E)-2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:2)
disodium 4-hydroxy-3-[(E)-(4-sulfonato-1-naphthyl)azo]naphthalene-1-sulfonate
EINECS 222-657-4
foodred5
4-hydroxy-3,4'-azo-bis-naphthalene-1-sulfonic acid,disodium-salt
red#14
Mordant Blue 79
Chromotrope FB
carmoisin
disodium 4-hydroxy-3-[(E)-(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate
AZORUBIN
Azorubine
Brilliant Crimson Red
MFCD00003978
E122
acidred2c
1-naphthalenesulfonic acid, 4-hydroxy-3-[(E)-(4-sulfo-1-naphthalenyl)azo]-, disodium salt
karmesin
Acid red 14
Carmoisine
ciacidred
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