1,10-Decanediol,2,2,9,9-tetramethyl-

Modify Date: 2024-01-02 18:16:58

1,10-Decanediol,2,2,9,9-tetramethyl- structure	Common Name	1,10-Decanediol,2,2,9,9-tetramethyl-
	CAS Number	35449-36-6	Molecular Weight	230.39
	Density	0.904g/cm3	Boiling Point	319.3ºC at 760mmHg
	Molecular Formula	C₁₄H₃₀O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	136.7ºC

Use of 1,10-Decanediol,2,2,9,9-tetramethyl-

Gemcadiol is a potent antilipemic agent. Gemcadiol has the potential for the research of hyperlipoproteinemia[1][2].

Name	2,2,9,9-tetramethyldecane-1,10-diol
Synonym	More Synonyms

Description	Gemcadiol is a potent antilipemic agent. Gemcadiol has the potential for the research of hyperlipoproteinemia[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	Gemcadiol (25-300 mg/kg；13 周) 降低猴子的血清胆固醇并略微增加血清肌酸磷酸激酶[2]。
References	[1]. Blumethal HP, et al. Gemcadiol: a new antilipemic drug, a clinical trial. Lipids. 1977 Jan;12(1):44-8. [2]. Fitzgerald JE, et al. Preclinical toxicology studies with the lipid-regulating agent gemcadiol. Fundam Appl Toxicol. 1986 Apr;6(3):520-31.

Density	0.904g/cm3
Boiling Point	319.3ºC at 760mmHg
Molecular Formula	C₁₄H₃₀O₂
Molecular Weight	230.39
Flash Point	136.7ºC
Exact Mass	230.22500
PSA	40.46000
LogP	3.36400
Index of Refraction	1.461

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HD8452000

CHEMICAL NAME :: 1,10-Decanediol, 2,2,9,9-tetramethyl-

CAS REGISTRY NUMBER :: 35449-36-6

BEILSTEIN REFERENCE NO. :: 1748265

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H30-O2

MOLECULAR WEIGHT :: 230.44

WISWESSER LINE NOTATION :: Q1X1&1&6X1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1023 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0064286

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1023 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/52W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 109 gm/kg/52W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986

HS Code	2905399090

2,2,9,9-tetrame...

CAS#:22092-62-2

1,10-Decanediol...

CAS#:35449-36-6

Literature: Adams; Anderson Journal of the American Chemical Society, 1951 , vol. 73, p. 136,141

N/A

CAS#:22092-67-7

1,10-Decanediol...

CAS#:35449-36-6

Literature: Adams; Anderson Journal of the American Chemical Society, 1951 , vol. 73, p. 136,141

N/A

CAS#:158300-02-8

1,10-Decanediol...

CAS#:35449-36-6

Literature: Adams; Anderson Journal of the American Chemical Society, 1951 , vol. 73, p. 136,141

Precursor 1
CAS#:22092-62-2 2,2,9,9-tetrame...
DownStream 0

HS Code	2905399090
Summary	2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Gemcadiol

2,2,9,9-tetramethyl-decane-1,10-diol

2,2,9,9-Tetramethyl-1,10-decanediol

CI-720

2,2,9,9-Tetramethyl-1,10-decandiol

2,2,9,9-Tetramethyl-decan-1,10-diol

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,10-Decanediol,2,2,9,9-tetramethyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Use of 1,10-Decanediol,2,2,9,9-tetramethyl-

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