339080-77-2

339080-77-2 structure

Name: (2,2,9,9-2H4)Decanedioic acid
Chemical Name: 1,10-decanedioic-2,2,9,9-d4 acid
CAS Number: 339080-77-2
Molecular Formula: C₁₀H₁₄D₄O₄
Molecular Weight: 206.272
Catalog: Research Areas Metabolic Disease
Create Date: 2018-08-05 18:23:24
Modify Date: 2024-01-20 18:32:19
Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].

Name	1,10-decanedioic-2,2,9,9-d4 acid
Synonyms	(2,2,9,9-H)Decanedioic acid Decanedioic-2,2,9,9-d acid

Description	Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Bertuzzi A, et al. Sebacic acid binding to human plasma albumin. Biochem Pharmacol. 1993 Feb 9;45(3):697-702.