LY-487379 hydrochloride
Modify Date: 2024-01-14 18:04:08
LY-487379 hydrochloride structure
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Common Name | LY-487379 hydrochloride | ||
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| CAS Number | 353229-59-1 | Molecular Weight | 488.90800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20ClF3N2O4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of LY-487379 hydrochlorideLY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research[2]. |
| Name | 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide,hydrochloride |
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| Description | LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research[2]. |
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| Related Catalog | |
| In Vivo | LY487379 hydrochloride (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage[1]. LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats[1]. |
| References |
| Molecular Formula | C21H20ClF3N2O4S |
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| Molecular Weight | 488.90800 |
| Exact Mass | 488.07800 |
| PSA | 77.11000 |
| LogP | 6.66400 |
| RIDADR | NONH for all modes of transport |
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