Ziyuglycoside II

Modify Date: 2025-08-25 19:03:28

Ziyuglycoside II structure	Common Name	Ziyuglycoside II
	CAS Number	35286-59-0	Molecular Weight	604.814
	Density	1.3±0.1 g/cm3	Boiling Point	716.2±60.0 °C at 760 mmHg
	Molecular Formula	C₃₅H₅₆O₈	Melting Point	260-263℃
	MSDS	N/A	Flash Point	218.6±26.4 °C

Use of Ziyuglycoside II

Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].

Name	(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
Synonym	More Synonyms

Description	Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Inflammation/Immunology
In Vitro	Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively[1]. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h[1]. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells[1]. Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent[1]. Cell Viability Assay[1] Cell Line: MDA-MB-435 cells Concentration: 10, 20, 30, 40, 50, 60 μM Incubation Time: 24 hours and 48 hours Result: The IC50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Cell Cycle Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Induced G0/G1 and S phase arrest. Apoptosis Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: The apoptotic rate was significantly increased in comparison to that of the control. Western Blot Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Treatment resulted in increased expressions of both p53 and p21.
References	[1]. Zhu X, et al. Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway. Int J Mol Sci. 2013 Sep 3;14(9):18041-55. [2]. Zhu X, et al. Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicol Lett. 2014 May 16;227(1):65-73.

Density	1.3±0.1 g/cm3
Boiling Point	716.2±60.0 °C at 760 mmHg
Melting Point	260-263℃
Molecular Formula	C₃₅H₅₆O₈
Molecular Weight	604.814
Flash Point	218.6±26.4 °C
Exact Mass	604.397522
PSA	136.68000
LogP	7.68
Vapour Pressure	0.0±5.2 mmHg at 25°C
Index of Refraction	1.588
InChIKey	MFIXLWYJTVEVGO-YHGWSDCJSA-N
SMILES	CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1(C)O
Storage condition	2-8°C