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  • Product Name: Ziyuglycoside II
  • Price: ￥Inquiry/20mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng
Related CAS#:
35286-59-0 815-84-9
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35286-59-0

35286-59-0 structure
35286-59-0 structure
  • Name: Ziyuglycoside II
  • Chemical Name: (3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
  • CAS Number: 35286-59-0
  • Molecular Formula: C35H56O8
  • Molecular Weight: 604.814
  • Catalog: Natural product Moss
  • Create Date: 2018-04-25 08:00:00
  • Modify Date: 2024-01-02 20:02:45
  • Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].
Name (3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
Synonyms Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-
zirconyl carbonate
(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
Ziyuglycoside II
Zirconium carbonate oxide
Description Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].
Related Catalog
In Vitro Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively[1]. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h[1]. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells[1]. Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent[1]. Cell Viability Assay[1] Cell Line: MDA-MB-435 cells Concentration: 10, 20, 30, 40, 50, 60 μM Incubation Time: 24 hours and 48 hours Result: The IC50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Cell Cycle Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Induced G0/G1 and S phase arrest. Apoptosis Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: The apoptotic rate was significantly increased in comparison to that of the control. Western Blot Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Treatment resulted in increased expressions of both p53 and p21.
References

[1]. Zhu X, et al. Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway. Int J Mol Sci. 2013 Sep 3;14(9):18041-55.

[2]. Zhu X, et al. Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicol Lett. 2014 May 16;227(1):65-73.
Density 1.3±0.1 g/cm3
Boiling Point 716.2±60.0 °C at 760 mmHg
Melting Point 260-263℃
Molecular Formula C35H56O8
Molecular Weight 604.814
Flash Point 218.6±26.4 °C
Exact Mass 604.397522
PSA 136.68000
LogP 7.68
Vapour Pressure 0.0±5.2 mmHg at 25°C
Index of Refraction 1.588
Storage condition 2-8°C
Precursor  2

DownStream  0


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