MLS000544460
Modify Date: 2024-01-11 15:02:05
MLS000544460 structure
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Common Name | MLS000544460 | ||
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| CAS Number | 352336-36-8 | Molecular Weight | 341.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H12FN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MLS000544460MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1]. |
| Name | MLS000544460 |
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| Description | MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
Kd: 2.0 μM (Eya2 phosphatase)[1] IC50: 4 μM (Eya2 phosphatase)[1] |
| In Vitro | MLS000544460 does not bind Eya3 phosphatase (ED)[1]. MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells[1]. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED[1]. |
| References |
| Molecular Formula | C17H12FN3O2S |
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| Molecular Weight | 341.36 |
| Hazard Codes | Xi |
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