Norgestimate

Modify Date: 2024-01-02 10:38:08

Norgestimate structure	Common Name	Norgestimate
	CAS Number	35189-28-7	Molecular Weight	369.497
	Density	1.2±0.1 g/cm3	Boiling Point	497.9±45.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₃₁NO₃	Melting Point	216ºC
	MSDS	Chinese USA	Flash Point	254.9±28.7 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Norgestimate

Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].

Name	norgestimate
Synonym	More Synonyms

Description	Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology
In Vitro	Norgestimate is converted to at least two active metabolites: levonorgestrel 3-oxime (deacetylated norgestimate; norelgestromin) and levonorgestrel[1].
References	[1]. Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68(10-13):879-90. [2]. Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1191-6.

Density	1.2±0.1 g/cm3
Boiling Point	497.9±45.0 °C at 760 mmHg
Melting Point	216ºC
Molecular Formula	C₂₃H₃₁NO₃
Molecular Weight	369.497
Flash Point	254.9±28.7 °C
Exact Mass	369.230408
PSA	58.89000
LogP	5.00
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.611

Norgestimate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JF7976000

CHEMICAL NAME :: 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)-

CAS REGISTRY NUMBER :: 35189-28-7

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H31-N-O3

MOLECULAR WEIGHT :: 369.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 mg/kg

SEX/DURATION :: female 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,541,1977

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H315-H319-H361fd
Precautionary Statements	P281-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	63-22-36/38-62
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport
RTECS	JF7976000

(8R,9S,10R,13S,...

CAS#:13732-69-9

~85%

Norgestimate

CAS#:35189-28-7

Literature: RICHTER GEDEON VEGYESZETI GYAR R.T. Patent: WO2005/868 A1, 2005 ; Location in patent: Page/Page column 5 ;

Precursor 1
CAS#:13732-69-9 (8R,9S,10R,13S,...
DownStream 0

Types of combined oral contraceptives used by US women.

Contraception 86(6) , 659-65, (2012)

We sought to estimate the prevalence of types of combined oral contraceptives (COCs) used among US women.We analyzed interview-collected data from 12,279 women aged 15-44 years participating in the Na...

Mechanosensitive ATP release from hemichannels and Ca²⁺ influx through TRPC6 accelerate wound closure in keratinocytes.

J. Cell Sci. 127(Pt 19) , 4159-71, (2014)

The study aimed to investigate the effect of inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) activity on tau phosphorylation in HEK293/tau441 cells and its mechanism. HEK293/tau441 cells were tre...

Progestins in preventive hormone therapy. Including pharmacology of the new progestins, desogestrel, norgestimate, and gestodene: are there advantages?

Obstet. Gynecol. Clin. North Am. 21(2) , 299-319, (1994)

Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofa...

(3E,8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

(+)-13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-20-yn-3-one Oxime Acetate (Ester)

d-17beta-acetoxy-13beta-ethyl-17alpha-ethinyl-gon-4en-3-one oxime

dexnorgestrelacetime

Norgestimat

Norgestimate

NORGESTIMATE,USP STANDARD

levonorgestrel acetate 3-oxime

(3E,8R,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ylacetat

acétate de (3E,8R,9S,10R,13S,14S,17R)-13-éthyl-17-éthynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yle

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Dayang Chem (Hangzhou) Co., Ltd.
China
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China
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Henan Tianfu Chemical Co., Ltd.
China
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Purity: 99.0%
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Norgestimate

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