Kuraridine
Modify Date: 2024-01-02 16:31:13
Kuraridine structure
|
Common Name | Kuraridine | ||
|---|---|---|---|---|
| CAS Number | 34981-25-4 | Molecular Weight | 438.51300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H30O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KuraridineKuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1]. |
| Name | Kuraridine |
|---|---|
| Synonym | More Synonyms |
| Description | Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
PDE5:0.64 μM (IC50) |
| In Vitro | Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1]. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2]. Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2]. |
| References |
| Molecular Formula | C26H30O6 |
|---|---|
| Molecular Weight | 438.51300 |
| Exact Mass | 438.20400 |
| PSA | 107.22000 |
| LogP | 5.50480 |
| 6'-methoxy-2,4,2',4'-tetrahydroxy-3'-lavandulylchalcone |
| kuraridin |
| kuraridine |
| (E)-1-[2,4-Dihydroxy-3-(2-isopropenyl-5-methyl-hex-4-enyl)-6-methoxy-phenyl]-3-(2,4-dihydroxy-phenyl)-propenone |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Kuraridine
- Price: Check
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- China
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Kuraridine
- Price: ￥4418.0/5mg
- Purity: 98.0%
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- DC Chemicals Limited
- China
- Product Name: Kuraridine
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Kuraridine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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