pyroglutamyl-phenylalanyl-prolinamide

Modify Date: 2024-01-10 21:55:20

pyroglutamyl-phenylalanyl-prolinamide structure	Common Name	pyroglutamyl-phenylalanyl-prolinamide
	CAS Number	34783-35-2	Molecular Weight	372.41800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of pyroglutamyl-phenylalanyl-prolinamide

[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin[1].

Name	L-pyroglutamyl-L-phenylalanine-L-proline amide
Synonym	More Synonyms

Description	[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor
In Vitro	[Phe2]-TRH对 TRH 受体的亲和力低于 TRH 本身，并且在 [Phe2, azPro3]-TRH 类似物中用 azPro 替代 Pro 导致亲和力进一步损失约 200 倍[1]。
References	[1]. Eckle E, et al. Conformational properties of central nervous system active thyrotropin releasing hormone analogues: probing structure-activity relationships at the molecular level. J Med Chem. 1985 Jan;28(1):125-37. [2]. Zhang WJ, et al. Impact of azaproline on amide cis-trans isomerism: conformational analyses and NMR studies of model peptides including TRH analogues. J Am Chem Soc. 2003 Feb 5;125(5):1221-35.

Glp-Phe-Pro-NH2

pyro-L-Glu-L-Phe-L-Pro-NH2

[Phe2]-TRH

pGlu-Phe-Pro-NH2

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