34783-35-2

34783-35-2 structure

Name: pyroglutamyl-phenylalanyl-prolinamide
Chemical Name: L-pyroglutamyl-L-phenylalanine-L-proline amide
CAS Number: 34783-35-2
Molecular Formula: C₁₉H₂₄N₄O₄
Molecular Weight: 372.41800
Catalog: Research Areas Endocrinology
Create Date: 2018-05-02 08:12:04
Modify Date: 2024-01-10 21:55:20
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin[1].

Name	L-pyroglutamyl-L-phenylalanine-L-proline amide
Synonyms	Glp-Phe-Pro-NH2 pyro-L-Glu-L-Phe-L-Pro-NH2 [Phe2]-TRH pGlu-Phe-Pro-NH2

Description	[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor
In Vitro	[Phe2]-TRH对 TRH 受体的亲和力低于 TRH 本身，并且在 [Phe2, azPro3]-TRH 类似物中用 azPro 替代 Pro 导致亲和力进一步损失约 200 倍[1]。
References	[1]. Eckle E, et al. Conformational properties of central nervous system active thyrotropin releasing hormone analogues: probing structure-activity relationships at the molecular level. J Med Chem. 1985 Jan;28(1):125-37. [2]. Zhang WJ, et al. Impact of azaproline on amide cis-trans isomerism: conformational analyses and NMR studies of model peptides including TRH analogues. J Am Chem Soc. 2003 Feb 5;125(5):1221-35.