cetraxate

Modify Date: 2024-01-13 18:55:23

cetraxate Structure
cetraxate structure
Common Name cetraxate
CAS Number 34675-84-8 Molecular Weight 305.36900
Density 1.182g/cm3 Boiling Point 480.9ºC at 760mmHg
Molecular Formula C17H23NO4 Melting Point N/A
MSDS N/A Flash Point 244.6ºC

 Use of cetraxate


Cetraxate is an orally active antiulcer Drug. Cetraxate increases the blood flow of gastric mucosal. Cetraxate increases the eradication of Helicobacter pylori in smokers when in combination with Omeprazole (HY-B0113),Amoxicillin (HY-B0467A), and Clarithromycin (HY-17508) [1].

 Names

Name cetraxate
Synonym More Synonyms

 cetraxate Biological Activity

Description Cetraxate is an orally active antiulcer Drug. Cetraxate increases the blood flow of gastric mucosal. Cetraxate increases the eradication of Helicobacter pylori in smokers when in combination with Omeprazole (HY-B0113),Amoxicillin (HY-B0467A), and Clarithromycin (HY-17508) [1].
Related Catalog
References

[1]. Kamada T, et al. Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers. Aliment Pharmacol Ther. 2000 Aug;14(8):1089-94.  

 Chemical & Physical Properties

Density 1.182g/cm3
Boiling Point 480.9ºC at 760mmHg
Molecular Formula C17H23NO4
Molecular Weight 305.36900
Flash Point 244.6ºC
Exact Mass 305.16300
PSA 89.62000
LogP 3.07460
Index of Refraction 1.551

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA8340500
CHEMICAL NAME :
Benzenepropanoic acid, 4-(((4-(aminomethyl)cyclohexyl)carbonyl)oxy)-, trans-
CAS REGISTRY NUMBER :
34675-84-8
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C17-H23-N-O4
MOLECULAR WEIGHT :
305.41
WISWESSER LINE NOTATION :
L6TJ AVOR D2VQ& D1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
716 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1503 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
681 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980

 Safety Information

HS Code 2922509090

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Cetraxate [INN]
Cetraxate
3-[4-[4-(aminomethyl)cyclohexanecarbonyl]oxyphenyl]propanoic acid
4'-(2-carboxyethyl)phenyl.trans-4-aminomethylcyclohexane carboxylate
trans-4-(((4-(Aminomethyl)cyclohexyl)carbonyl)oxy)benzenepropanoic acid
Cetraxato [INN-Spanish]
3-[4-({[4-(aminomethyl)cyclohexyl]carbonyl}oxy)phenyl]propanoic acid
Cetraxatum [INN-Latin]
p-hydroxyhydrocinnamic acid trans-(4-aminomethyl)cyclohexanecarboxylate
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