EMI48
Modify Date: 2024-01-02 11:50:04
EMI48 structure
|
Common Name | EMI48 | ||
|---|---|---|---|---|
| CAS Number | 34564-13-1 | Molecular Weight | 348.39500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EMI48EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1]. |
| Name | 7-(diethylamino)-3-(5-methyl-1,3-benzoxazol-2-yl)chromen-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFRL858R/T790M/C797S EGFRdel19 T790M C797S |
| In Vitro | EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1]. |
| References |
| Molecular Formula | C21H20N2O3 |
|---|---|
| Molecular Weight | 348.39500 |
| Exact Mass | 348.14700 |
| PSA | 59.48000 |
| LogP | 4.75580 |
|
~87%
EMI48 CAS#:34564-13-1 |
| Literature: Nourmohammadian, Farahnaz; Gholami, Mahnaz Davoodzadeh Synthetic Communications, 2010 , vol. 40, # 6 p. 901 - 909 |
|
~66%
EMI48 CAS#:34564-13-1 |
| Literature: Nourmohammadian, Farahnaz; Gholami, Mahnaz Davoodzadeh Synthetic Communications, 2010 , vol. 40, # 6 p. 901 - 909 |
| EINECS 252-093-4 |
| disperse yellow 184 |