34564-13-1

34564-13-1 structure

Name: EMI48
Chemical Name: 7-(diethylamino)-3-(5-methyl-1,3-benzoxazol-2-yl)chromen-2-one
CAS Number: 34564-13-1
Molecular Formula: C₂₁H₂₀N₂O₃
Molecular Weight: 348.39500
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2016-09-29 01:56:26
Modify Date: 2024-01-02 11:50:04
EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].

Name	7-(diethylamino)-3-(5-methyl-1,3-benzoxazol-2-yl)chromen-2-one
Synonyms	EINECS 252-093-4 disperse yellow 184

Description	EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFRL858R/T790M/C797S EGFRdel19 T790M C797S
In Vitro	EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].
References	[1]. Punit Saraon , et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16(5):577-586.