3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE

Modify Date: 2024-04-02 17:08:48

3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE Structure
3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE structure
Common Name 3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE
CAS Number 341944-06-7 Molecular Weight 240.713
Density 1.5±0.1 g/cm3 Boiling Point 488.6±47.0 °C at 760 mmHg
Molecular Formula C9H9ClN4S Melting Point N/A
MSDS N/A Flash Point 249.3±29.3 °C

 Use of 3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE


Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].

 Names

Name 3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine
Synonym More Synonyms

  Biological Activity

Description Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].
Related Catalog
Target

IC50: 15 μM (RpMetAP1)[1]

In Vitro Antibacterial agent 117 can inhibit RpMetAP1 with an IC50 value of 15 μM[1]. Antibacterial agent 117 (0.3 μM, 3 μM, 30 μM and 300 μM) stimulates endothelial cell (EC) metabolism and also inhibits rickettsial growth[1].
References

[1]. Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 488.6±47.0 °C at 760 mmHg
Molecular Formula C9H9ClN4S
Molecular Weight 240.713
Flash Point 249.3±29.3 °C
Exact Mass 240.023651
LogP 2.41
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.699
Storage condition 2-8°C

 Synonyms

1H-1,2,4-Triazol-5-amine, 3-[[(2-chlorophenyl)methyl]thio]-
MFCD00215049
3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine
4H-1,2,4-triazol-3-amine, 5-[[(2-chlorophenyl)methyl]thio]-
5-[(2-Chlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
MFCD03847132
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Price: ¥600/5 mg

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