Pterosin B

Modify Date: 2024-01-05 21:47:45

Pterosin B Structure
Pterosin B structure
Common Name Pterosin B
CAS Number 34175-96-7 Molecular Weight 218.292
Density 1.1±0.1 g/cm3 Boiling Point 396.5±41.0 °C at 760 mmHg
Molecular Formula C14H18O2 Melting Point N/A
MSDS N/A Flash Point 169.3±20.2 °C

 Use of Pterosin B


Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3[1][2].

 Names

Name (R)-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one
Synonym More Synonyms

 Pterosin B Biological Activity

Description Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3[1][2].
Related Catalog
Target

SIK3

References

[1]. Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.

[2]. Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 396.5±41.0 °C at 760 mmHg
Molecular Formula C14H18O2
Molecular Weight 218.292
Flash Point 169.3±20.2 °C
Exact Mass 218.130676
PSA 37.30000
LogP 2.65
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.560

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK7537730
CHEMICAL NAME :
1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-
CAS REGISTRY NUMBER :
34175-96-7
LAST UPDATED :
198703
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H18-O2
MOLECULAR WEIGHT :
218.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
100 mg/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,829,1975

 Safety Information

Hazard Codes Xi
HS Code 2914400090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-
6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one
1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-
6-(2-Hydroxyethyl)-2,5,7-trimethyl-1-indanone
Pterosin B