Homobutein

Modify Date: 2025-08-25 20:38:41

Homobutein structure	Common Name	Homobutein
	CAS Number	34000-39-0	Molecular Weight	286.27900
	Density	1.369 g/cm3	Boiling Point	523.8ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₄O₅	Melting Point	207-212ºC
	MSDS	N/A	Flash Point	197.6ºC

Use of Homobutein

Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].

Name	(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
Synonym	More Synonyms

Description	Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
In Vitro	Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1]. Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1]. Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2]. Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 µM, respectively[3]. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 20, 24, 28, 32, 40 μM Incubation Time: 2 h Result: Showed inhibition of viability in K562 cells. Cell Viability Assay[2] Cell Line: Toxoplasma gondii RH-2F strain Concentration: 1 μg/mL Incubation Time: 72 h Result: Surpressed 19.48% of the Toxoplasma gondii.
References	[1]. Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. [2]. Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383. [3]. Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32. [4]. Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.

Density	1.369 g/cm3
Boiling Point	523.8ºC at 760 mmHg
Melting Point	207-212ºC
Molecular Formula	C₁₆H₁₄O₅
Molecular Weight	286.27900
Flash Point	197.6ºC
Exact Mass	286.08400
PSA	86.99000
LogP	2.70810
Index of Refraction	1.684

HS Code	2914509090

Precursor 6
CAS#:89-84-9 2,4-Dihydroxyac... CAS#:121-33-5 Vanillin CAS#:67756-04-1 1-(2,4-dimethox... CAS#:5460-32-2 4-Iodo-1,2-dime...
CAS#:65490-08-6 1-[2-hydroxy-4-... CAS#:5533-00-6 3-methoxy-4-(me...
DownStream 1
CAS#:21913-98-4 3'-Methoxydaidzein

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2',4,4'-trihydroxy-3-methoxychalcone

2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)

3-O-Methylbutein

1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one

(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one

EINECS 251-782-7

2',4,4'-trihydroxy-3-dimethoxychalcone

4,2',4'-trihydroxy-3-methoxy-trans-chalcone

Acrylophenone,2',4'-dihydroxy-3-(p-hydroxy-m-methoxyphenyl)

4,2',4'-Trihydroxy-3-methoxy-trans-chalkon

Homobutein

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HOMOBUTEIN
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: HOMOBUTEIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Homobutein

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.