Dihydrouracil-d4

Modify Date: 2024-01-10 17:54:21

Dihydrouracil-d4 structure	Common Name	Dihydrouracil-d4
	CAS Number	334473-41-5	Molecular Weight	118.12700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄H₂D₄N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dihydrouracil-d4

Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].

Name	[5,5,6,6-2H4]-dihydrouracil

Description	Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化，可能影响药物的药代动力学和代谢特征，受到广泛关注[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769. [3]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744.

Molecular Formula	C₄H₂D₄N₂O₂
Molecular Weight	118.12700
Exact Mass	118.06800
PSA	58.20000

Precursor 0
DownStream 1
CAS#:116173-67-2 β-(2,2,3,3-2H4)...