334473-41-5

334473-41-5 structure

Name: Dihydrouracil-d4
Chemical Name: [5,5,6,6-2H4]-dihydrouracil
CAS Number: 334473-41-5
Molecular Formula: C₄H₂D₄N₂O₂
Molecular Weight: 118.12700
Catalog: Research Areas Metabolic Disease
Create Date: 2016-04-19 20:56:21
Modify Date: 2024-01-10 17:54:21
Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].

Name	[5,5,6,6-2H4]-dihydrouracil

Description	Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化，可能影响药物的药代动力学和代谢特征，受到广泛关注[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769. [3]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744.

Precursor 0
DownStream 1
116173-67-2