STOCK2S 26016

Modify Date: 2024-04-09 16:11:22

STOCK2S 26016 Structure
STOCK2S 26016 structure
Common Name STOCK2S 26016
CAS Number 332922-63-1 Molecular Weight 333.38
Density N/A Boiling Point N/A
Molecular Formula C20H19N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of STOCK2S 26016


STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with the IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research[1].

 Names

Name STOCK2S-26016

 STOCK2S 26016 Biological Activity

Description STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with the IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research[1].
Related Catalog
Target

IC50: 16 μM (WNK4); 34.4 μM (WNK1)[1]

In Vitro STOCK2S-26016 (10 and 30 minutes) blocks the effect of L-NAME on phosphorylated sodium-chloride cotransporter (NCC) in mDCT cells[2]. STOCK2S-26016 (25-200 μM) drastically and dose-dependently reduces the phosphorylation of STE20/SPS1-related proline/alanine-rich protein kinase (SPAK) and NCC in mpkDCT cells[1]. STOCK2S-26016 (50-200 μM) drastically and dose-dependently reduces the phosphorylation of SPAK and Na/K/Cl cotransporter 1 (NKCC1) in MOVAS cells[1].
References

[1]. Takayasu M, et, al. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem J. 2013 Nov 1; 455(3): 339-45.

[2]. Conghui W, et, al. Low dose L-NAME induces salt sensitivity associated with sustained increased blood volume and sodium-chloride cotransporter activity in rodents. Kidney Int. 2020 Jun 24; S0085-2538(20)30703-1.

 Chemical & Physical Properties

Molecular Formula C20H19N3O2
Molecular Weight 333.38
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.