Pargluva

Modify Date: 2024-01-08 17:34:08

Pargluva Structure
Pargluva structure
Common Name Pargluva
CAS Number 331741-94-7 Molecular Weight 516.54200
Density 1.274g/cm3 Boiling Point 736.4ºC at 760 mmHg
Molecular Formula C29H28N2O7 Melting Point N/A
MSDS N/A Flash Point 399.2ºC

 Use of Pargluva


Muraglitazar is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα (EC50 = 320 nM) and PPARγ(EC50 = 110 nM)[1].

 Names

Name Muraglitazar
Synonym More Synonyms

 Pargluva Biological Activity

Description Muraglitazar is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα (EC50 = 320 nM) and PPARγ(EC50 = 110 nM)[1].
Related Catalog
References

[1]. Buse JB, Rubin CJ, Frederich R, et al. Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther. 2005;27(8):1181-1195.

[2]. Cox SL. Muraglitazar: an agent for the treatment of type 2 diabetes and associated dyslipidemia. Drugs Today (Barc). 2005;41(9):579-587.

 Chemical & Physical Properties

Density 1.274g/cm3
Boiling Point 736.4ºC at 760 mmHg
Molecular Formula C29H28N2O7
Molecular Weight 516.54200
Flash Point 399.2ºC
Exact Mass 516.19000
PSA 120.12000
LogP 4.81940
Index of Refraction 1.601

 Synonyms

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid
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