ζ-Stat
Modify Date: 2024-01-09 10:10:07
ζ-Stat structure
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Common Name | ζ-Stat | ||
|---|---|---|---|---|
| CAS Number | 3316-02-7 | Molecular Weight | 384.36000 | |
| Density | 2.019g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H8O10S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ζ-Statζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. |
| Name | 8-hydroxynaphthalene-1,3,6-trisulfonic acid |
|---|---|
| Synonym | More Synonyms |
| Description | ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. |
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| Related Catalog | |
| Target |
aPKC-ζ:5 μM (IC50) |
| In Vitro | ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1]. ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1]. ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2]. ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1]. ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. Cell Proliferation Assay[1] Cell Line: MEL-F-NEO, SK-MEL-2 and MeWo cells Concentration: 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM Incubation Time: 3 days Result: Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells. Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM. Western Blot Analysis[1] Cell Line: SK-MEL-2 and MeWo cells Concentration: 5 µM Incubation Time: 3 days Result: Decreased phosphorylated and total PKC-ζ levels. |
| References |
| Density | 2.019g/cm3 |
|---|---|
| Molecular Formula | C10H8O10S3 |
| Molecular Weight | 384.36000 |
| Exact Mass | 383.92800 |
| PSA | 208.48000 |
| LogP | 3.52790 |
| Index of Refraction | 1.741 |
| HS Code | 2908999090 |
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| Precursor 0 | |
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| DownStream 1 | |
CAS#:148-25-4| HS Code | 2908999090 |
|---|---|
| Summary | 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
| 1-Naphthol,6,8-trisulfo |
| 1-naphthol-3,6,8-trisulfonic acid |
| 8-Hydroxy-naphthalin-1,3,6-trisulfonsaeure |
| 8-hydroxy-naphthalene-1,3,6-trisulfonic acid |
| 1-Naphthol,3,6,8-trisulfo |
| Naphthol-(1)-trisulfonsaeure-(3.6.8) |
| 1-naphthol-3,6,8-trisulphonic acid |
| 1-Naphthylamin-3,6,8-trisulfonsaeure |