Phortress

Modify Date: 2024-01-14 07:19:19

Use of Phortress

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].

Name	AXR52N9SMF
Synonym	More Synonyms

Description	Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
References	[1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54. [2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.

Description

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

References

MFCD06407804

AXR52N9SMF

N-[4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]-L-lysinamide dihydrochloride

Hexanamide, 2,6-diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]-, (2S)-, hydrochloride (1:2)

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