328087-38-3

328087-38-3 structure

Name: Phortress
Chemical Name: AXR52N9SMF
CAS Number: 328087-38-3
Molecular Formula: C₂₀H₂₅Cl₂FN₄OS
Molecular Weight: 459.408
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2018-07-03 11:15:37
Modify Date: 2024-01-14 07:19:19
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].

Name	AXR52N9SMF
Synonyms	MFCD06407804 AXR52N9SMF N-[4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]-L-lysinamide dihydrochloride Hexanamide, 2,6-diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]-, (2S)-, hydrochloride (1:2)

Description	Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
References	[1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54. [2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.