ERRγ agonist-2

Modify Date: 2024-04-06 13:52:26

ERRγ agonist-2 structure	Common Name	ERRγ agonist-2
	CAS Number	324022-01-7	Molecular Weight	447.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₁N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERRγ agonist-2

ERRγ agonist-2 is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ agonist-2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ agonist-2 has antimicrobial, anti-coagulant and antidiabetic activities[1].

Name	ERRγ agonist-2

Description	ERRγ agonist-2 is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ agonist-2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ agonist-2 has antimicrobial, anti-coagulant and antidiabetic activities[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Infection Research Areas >> Metabolic Disease
Target	ERRγ:6.5 μM (Kd)
In Vitro	ERRγ agonist-2 (1-10 μM; 293T 细胞) 抑制 ERRγ 的 PGC-1α 依赖性转录活性，对 ERRα 和 ERRβ 的抑制作用微弱[1]。 ERRγ agonist-2 (10 μM; AML12 细胞) 抑制铁调素、纤维蛋白原和糖异生基因的表达[1]。
References	[1]. Yang SH, et, al. Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists. Eur J Med Chem. 2023 Mar 15;250:115174.

Molecular Formula	C₂₇H₂₁N₅O₂
Molecular Weight	447.49

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ERRγ agonist-2

Use of ERRγ agonist-2

Names

ERRγ agonist-2 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.