SLC26A3-IN-1

Modify Date: 2024-09-23 11:08:01

SLC26A3-IN-1 Structure
SLC26A3-IN-1 structure
Common Name SLC26A3-IN-1
CAS Number 307552-53-0 Molecular Weight 358.39
Density N/A Boiling Point N/A
Molecular Formula C23H18O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SLC26A3-IN-1


SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].

 Names

Name SLC26A3-IN-1

 SLC26A3-IN-1 Biological Activity

Description SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
Related Catalog
In Vitro SLC26A3-IN-1 (化合物4a) (10 μM; 10 min) 对 SLC26A3 的抑制率为 87%[1]。
References

[1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.  

 Chemical & Physical Properties

Molecular Formula C23H18O4
Molecular Weight 358.39
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