307552-53-0

307552-53-0 structure

Name: SLC26A3-IN-1
Chemical Name: SLC26A3-IN-1
CAS Number: 307552-53-0
Molecular Formula: C₂₃H₁₈O₄
Molecular Weight: 358.39
Catalog: Research Areas Metabolic Disease
Create Date: 2023-07-08 08:56:10
Modify Date: 2024-09-23 11:08:01
SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].

Name	SLC26A3-IN-1

Description	SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	SLC26A3-IN-1 (化合物4a) (10 μM; 10 min) 对 SLC26A3 的抑制率为 87%[1]。
References	[1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.

Molecular Formula	C₂₃H₁₈O₄
Molecular Weight	358.39