Cyclopamine-KAAD
Modify Date: 2025-09-13 20:15:38
Cyclopamine-KAAD structure
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Common Name | Cyclopamine-KAAD | ||
|---|---|---|---|---|
| CAS Number | 306387-90-6 | Molecular Weight | 697.99 | |
| Density | 1.15g/cm3 | Boiling Point | 875.6ºC at 760 mmHg | |
| Molecular Formula | C44H63N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 483.3ºC | |
Use of Cyclopamine-KAADKAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1]. |
| Name | N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide |
|---|---|
| Synonym | More Synonyms |
| Description | KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1]. |
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| Related Catalog | |
| In Vitro | KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50 of 3 nM, wheras this cyclopamine derivative has an IC50 of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1]. |
| References |
| Density | 1.15g/cm3 |
|---|---|
| Boiling Point | 875.6ºC at 760 mmHg |
| Molecular Formula | C44H63N3O4 |
| Molecular Weight | 697.99 |
| Flash Point | 483.3ºC |
| Exact Mass | 697.48200 |
| PSA | 101.73000 |
| LogP | 8.40240 |
| Index of Refraction | 1.588 |
| InChIKey | WDHRPWOAMDJICD-BWBMXWGBSA-N |
| SMILES | CC1=C2CC3C(CC=C4CC(=O)CCC43C)C2CCC12OC1CC(C)CN(CCNC(=O)CCCCCNC(=O)CCc3ccccc3)C1C2C |
| Hazard Codes | Xi |
|---|
| Cyclopamine-KAAD |
| Shh Signaling Antagonist II |
| 3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine |
| KAAD-Cyclopamine |