(R)-MLN-4760

Modify Date: 2024-01-10 19:21:05

Use of (R)-MLN-4760

(R)-MLN-4760, the R-enantiomer of MLN-4760, is an ACE2 inhibitor, with an IC50 of 8.4 μM. (R)-MLN-4760 is the less active isomer[1].

Name	(R)-MLN-4760

Description	(R)-MLN-4760, the R-enantiomer of MLN-4760, is an ACE2 inhibitor, with an IC50 of 8.4 μM. (R)-MLN-4760 is the less active isomer[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 8.4 nM (ACE2)[1]
In Vitro	(R)-MLN-4760 (compound 16RS) is the less active isomer of MLN-4760[1].
References	[1]. Dales NA, et, al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.

Molecular Formula	C₁₉H₂₃Cl₂N₃O₄
Molecular Weight	428.31

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