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(R)-MLN-4760

Names

[ CAS No. ]:
305335-29-9

[ Name ]:
(R)-MLN-4760

Biological Activity

[Description]:

(R)-MLN-4760, the R-enantiomer of MLN-4760, is an ACE2 inhibitor, with an IC50 of 8.4 μM. (R)-MLN-4760 is the less active isomer[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[Target]

IC50: 8.4 nM (ACE2)[1]


[In Vitro]

(R)-MLN-4760 (compound 16RS) is the less active isomer of MLN-4760[1].

[References]

[1]. Dales NA, et, al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23Cl2N3O4

[ Molecular Weight ]:
428.31

Related Compounds