HDAC1/CDK7-IN-1

Modify Date: 2025-08-24 11:02:38

HDAC1/CDK7-IN-1 structure	Common Name	HDAC1/CDK7-IN-1
	CAS Number	2987905-95-1	Molecular Weight	626.10
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₃₂ClN₇O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC1/CDK7-IN-1

HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].

Name	HDAC1/CDK7-IN-1

Description	HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	CDK7:893 nM (IC50) HDAC1:248 nM (IC50)
References	[1]. Yao Chen, et al. Discovery of a Dual-Target Inhibitor of CDK7 and HDAC1 That Induces Apoptosis and Inhibits Migration in Colorectal Cancer. ChemMedChem. 2023 Oct 11:e202300281.

Molecular Formula	C₃₃H₃₂ClN₇O₄
Molecular Weight	626.10

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HDAC1/CDK7-IN-1

Use of HDAC1/CDK7-IN-1

Names

HDAC1/CDK7-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.