MORACIZINE HYDROCHLORIDE

Modify Date: 2025-08-22 19:40:25

MORACIZINE HYDROCHLORIDE Structure
MORACIZINE HYDROCHLORIDE structure
 Common Name MORACIZINE HYDROCHLORIDE
CAS Number 29560-58-5 Molecular Weight 463.97800
Density N/A Boiling Point 625ºC at 760 mmHg
Molecular Formula C22H26ClN3O4S Melting Point N/A
MSDS N/A Flash Point 331.8ºC

 Use of MORACIZINE HYDROCHLORIDE


Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1].

 Names

Name moricizine hydrochloride
Synonym More Synonyms

 MORACIZINE HYDROCHLORIDE Biological Activity

Description Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1].
Related Catalog
References

[1]. Bigger JT Jr. Cardiac electrophysiologic effects of moricizine hydrochloride. Am J Cardiol. 1990 Feb 20;65(8):15D-20D; discussion 68D-71D.

 Chemical & Physical Properties

Boiling Point 625ºC at 760 mmHg
Molecular Formula C22H26ClN3O4S
Molecular Weight 463.97800
Flash Point 331.8ºC
Exact Mass 463.13300
PSA 96.41000
LogP 4.98450
Vapour Pressure 1.54E-15mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN6500000
CHEMICAL NAME :
Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester, hydrochloride
CAS REGISTRY NUMBER :
29560-58-5
LAST UPDATED :
199803
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C22-H25-N3-O4-S.Cl-H
MOLECULAR WEIGHT :
464.02
WISWESSER LINE NOTATION :
T C666 BN ISJ EMVO2 B2V- AT6N DOTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(1),60,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,74,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
31 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,640,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(5),43,1985

 Safety Information

HS Code 2934999090

 Synthetic Route

ETHYL 10-(B-CHLOROPROPIONYL)PHENOTHIAZINE-2-CARBAMATE structure

ETHYL 10-(B-CHL...

CAS#:34749-22-9

~%

MORACIZINE HYDROCHLORIDE Structure

MORACIZINE HYDR...

CAS#:29560-58-5

Literature: Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488
morpholine structure

morpholine

CAS#:110-91-8

N/A structure

N/A

CAS#:94989-94-3

~53%

MORACIZINE HYDROCHLORIDE Structure

MORACIZINE HYDR...

CAS#:29560-58-5

Literature: Gritsenko, A. N.; Skoldinov, A. P. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 485 - 488
ethyl phenothiazine-2-carbamate structure

ethyl phenothia...

CAS#:37711-29-8

~%

MORACIZINE HYDROCHLORIDE Structure

MORACIZINE HYDR...

CAS#:29560-58-5

Literature: Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Moracizin-HCl
ethmozoine hydrochloride
Etmozin
Moricizine HCl
Ethmosine
UNII-71OK3Z1ESP
Ethmozin
ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate,hydrochloride
Moracizine hydrochloride
EN 313
MORICIZINE HYDROCHLORIDE
Ethmozine
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