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Product Name: MORACIZINE HYDROCHLORIDE
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Purity: 98.0%
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29560-58-5

29560-58-5 structure

Name: MORACIZINE HYDROCHLORIDE
Chemical Name: moricizine hydrochloride
CAS Number: 29560-58-5
Molecular Formula: C₂₂H₂₆ClN₃O₄S
Molecular Weight: 463.97800
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-06-28 16:29:24
Modify Date: 2025-08-22 19:40:25
Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1].

Name	moricizine hydrochloride
Synonyms	Moracizin-HCl ethmozoine hydrochloride Etmozin Moricizine HCl Ethmosine UNII-71OK3Z1ESP Ethmozin ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate,hydrochloride Moracizine hydrochloride EN 313 MORICIZINE HYDROCHLORIDE Ethmozine

Description	Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Bigger JT Jr. Cardiac electrophysiologic effects of moricizine hydrochloride. Am J Cardiol. 1990 Feb 20;65(8):15D-20D; discussion 68D-71D.

Boiling Point	625ºC at 760 mmHg
Molecular Formula	C₂₂H₂₆ClN₃O₄S
Molecular Weight	463.97800
Flash Point	331.8ºC
Exact Mass	463.13300
PSA	96.41000
LogP	4.98450
Vapour Pressure	1.54E-15mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN6500000

CHEMICAL NAME :: Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 29560-58-5

LAST UPDATED :: 199803

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C22-H25-N3-O4-S.Cl-H

MOLECULAR WEIGHT :: 464.02

WISWESSER LINE NOTATION :: T C666 BN ISJ EMVO2 B2V- AT6N DOTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(1),60,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 131 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,74,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,640,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(5),43,1985

HS Code	2934999090

34749-22-9

29560-58-5

Literature: Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488

110-91-8

94989-94-3

~53%

29560-58-5

Literature: Gritsenko, A. N.; Skoldinov, A. P. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 485 - 488

37711-29-8

29560-58-5

Literature: Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488

Precursor 3
110-91-8 34749-22-9 37711-29-8
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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