WU-04

Modify Date: 2025-08-26 18:53:37

WU-04 Structure
WU-04 structure
Common Name WU-04
CAS Number 2921711-74-0 Molecular Weight 526.38
Density N/A Boiling Point N/A
Molecular Formula C24H24BrN5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WU-04


WU-04 is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. WU-04 has high inhibitory effect on the 3CLpro protein of 6 SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda and Omicron) and 2 coronaviruses (SARS-CoV and MERS-CoV)[1].

 Names

Name WU-04

 WU-04 Biological Activity

Description WU-04 is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. WU-04 has high inhibitory effect on the 3CLpro protein of 6 SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda and Omicron) and 2 coronaviruses (SARS-CoV and MERS-CoV)[1].
Related Catalog
References

[1]. Wu J, et al. The molecular mechanism of non-covalent inhibitor WU-04 targeting SARS-CoV-2 3CLpro and computational evaluation of its effectiveness against mainstream coronaviruses. Phys Chem Chem Phys. 2023 Sep 13;25(35):23555-23567.. .  

 Chemical & Physical Properties

Molecular Formula C24H24BrN5O4
Molecular Weight 526.38
InChIKey BPLNOSFMIIASSJ-UXHICEINSA-N
SMILES CNC(=O)c1cc(Br)cc([N+](=O)[O-])c1NC1CCCCC1NC(=O)c1cncc2ccccc12
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