HDAC-IN-63

Modify Date: 2025-09-23 12:19:05

HDAC-IN-63 Structure
HDAC-IN-63 structure
Common Name HDAC-IN-63
CAS Number 2920046-95-1 Molecular Weight 529.42
Density N/A Boiling Point N/A
Molecular Formula C25H26Cl2N6O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HDAC-IN-63


HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].

 Names

Name HDAC-IN-63

 HDAC-IN-63 Biological Activity

Description HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].
Related Catalog
Target

0.844 and 30.0 nM for FLT3 and HDAC1[1]

References

[1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.  

 Chemical & Physical Properties

Molecular Formula C25H26Cl2N6O3
Molecular Weight 529.42
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