S1PR1 Radioligand 1

Modify Date: 2024-01-14 15:11:27

S1PR1 Radioligand 1 Structure
S1PR1 Radioligand 1 structure
Common Name S1PR1 Radioligand 1
CAS Number 2845249-11-6 Molecular Weight 471.42
Density N/A Boiling Point N/A
Molecular Formula C22H22F5N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of S1PR1 Radioligand 1


S1PR1 Radioligand 1(compound 6 h) is a specific S1PR1 radioligand with IC50 = 8.7 nM. S1PR1 Radioligand 1 has good brain uptake and can be used as a S1PR1-specific F-18 radiotracer for studying the function of S1PR1 in brain diseases[1].

 Names

Name S1PR1 Radioligand 1

 S1PR1 Radioligand 1 Biological Activity

Description S1PR1 Radioligand 1(compound 6 h) is a specific S1PR1 radioligand with IC50 = 8.7 nM. S1PR1 Radioligand 1 has good brain uptake and can be used as a S1PR1-specific F-18 radiotracer for studying the function of S1PR1 in brain diseases[1].
Related Catalog
In Vivo S1PR1 Radioligand 1(compound 6 h) 在 SD大鼠的肺、肝和肾中摄取相对较高。其中肺摄取最高,为 9.32±0.94 (%ID/g),其次为肝脏、肾脏、脾脏、胰腺、心脏和小肠,分别为 4.57±0.16、3.57±0.17、1.90±0.32、1.68±0.14、1.41±0.10和1.06±0.19(%ID/g)[1]。
References

[1]. Lin Qiu, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023 Mar 16.   

 Chemical & Physical Properties

Molecular Formula C22H22F5N3O3
Molecular Weight 471.42