LC-MB12

Modify Date: 2025-08-31 12:01:07

LC-MB12 structure	Common Name	LC-MB12
	CAS Number	2828438-38-4	Molecular Weight	899.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₃H₄₄Cl₂N₁₀O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LC-MB12

LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].

Name	LC-MB12

Description	LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR2:11.8 nM (DC50)
References	[1]. Ma L, et al. Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. J Med Chem. 2023 Jun 8;66(11):7438-7453.

Molecular Formula	C₄₃H₄₄Cl₂N₁₀O₈
Molecular Weight	899.78

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LC-MB12

Use of LC-MB12

Names

LC-MB12 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.