LC-MB12

Names

[ CAS No. ]:
2828438-38-4

[ Name ]:
LC-MB12

Biological Activity

[Description]:

LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR2:11.8 nM (DC50)


[References]

[1]. Ma L, et al. Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. J Med Chem. 2023 Jun 8;66(11):7438-7453.  

Chemical & Physical Properties

[ Molecular Formula ]:
C43H44Cl2N10O8

[ Molecular Weight ]:
899.78

Related Compounds