HDAC-IN-56

Modify Date: 2024-09-16 09:54:11

HDAC-IN-56 structure	Common Name	HDAC-IN-56
	CAS Number	2814571-89-4	Molecular Weight	485.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₈FN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC-IN-56

HDAC-IN-56 ((S)-17b) is an orally active class I histone deacetylase (HDAC) inhibitor with IC50 values of 56.0 ± 6.0, 90.0 ± 5.9, 422.2 ± 105.1, >10000 nM for HDAC1, HDAC2, HDAC3, and HDAC4-11, respectively. HDAC-IN-56 has potent inhibitory activity while strongly increasing intracellular levels of acetylhistone H3 and P21 and effectively inducing G1 cell cycle arrest and apoptosis.HDAC-IN-56 has antitumor activity [1].

Name	HDAC-IN-56

Description	HDAC-IN-56 ((S)-17b) is an orally active class I histone deacetylase (HDAC) inhibitor with IC50 values of 56.0 ± 6.0, 90.0 ± 5.9, 422.2 ± 105.1, >10000 nM for HDAC1, HDAC2, HDAC3, and HDAC4-11, respectively. HDAC-IN-56 has potent inhibitory activity while strongly increasing intracellular levels of acetylhistone H3 and P21 and effectively inducing G1 cell cycle arrest and apoptosis.HDAC-IN-56 has antitumor activity [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:56.0 nM (IC50) HDAC2:90.0 nM (IC50) HDAC3:422.2 nM (IC50)
References	[1]. Li D, et al. Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl) benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate. J Med Chem. 2023 May 25;66(10):7016-7037.

Molecular Formula	C₂₈H₂₈FN₅O₂
Molecular Weight	485.55

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HDAC-IN-56

Use of HDAC-IN-56

Names

HDAC-IN-56 Biological Activity

Chemical & Physical Properties